Radical cascade cyanomethylation of activated alkenes to construct cyano substituted oxindoles.
نویسندگان
چکیده
The cyanomethyl radical was easily generated from acetonitrile by using DTBP, which was applied to a cascade alkene addition and cyclization reaction to construct useful oxindole derivatives. This protocol features simple manipulation, cheap reagents and a broad substrate scope. In addition, nitro substituted oxindoles were also synthesized for the first time.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 95 شماره
صفحات -
تاریخ انتشار 2014